THE UNIVERSITY OF BRITISH COLUMBIA
RESEARCH IN COPD
Understanding resource utilization and mortality in COPD to support policy making: A microsimulation study
The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that are at increased risk of emergency department visits, hospitalization and mortality and 2) health economists to obtain input or va...
The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that ar...
The Long-Term Burden of COPD Exacerbations During Maintenance Therapy and Lung Function Decline
There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly in those with mild disease. Lung function decline is most accelerated at the early stages of COPD, and early identification of p...
There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly...
Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?
Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.
Predicting Severe COPD Exacerbations: Developing a Population Surveillance Approach with Administrative Data
Ann Am Thorac Soc. 2020 May 8.
Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study
Respir Res. 2020 May 19;21(1):118
Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline
The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologic management of COPD. The expert panel, in collaboration with a team of methodologists, prioritized and developed six questions...
The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologi...
Looking at the COPD spectrum through “PRISm”
A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD" by Wijnant et al. Given that PRISm resembles COPD in term of reduction in FEV1, but not in terms of FEV1/FVC r...
A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close...
Individualized prediction of lung-function decline in chronic obstructive pulmonary disease
The Impact of Care Specialty on Survival-Adjusted Medical Costs of COPD Patients After a Hospitalization: a longitudinal analysis.
J Gen Intern Med. 2018 Sep;33(9):1528-1535
The diagnostic performance of patient symptoms in screening for COPD
Respir Res. 2018 Feb 7;19(1):26
Characterizing undiagnosed chronic obstructive pulmonary disease: a systematic review and meta-analysis
Chest. 2015 Apr;147(4):868-869
The global economic burden of asthma and chronic obstructive pulmonary disease
Int J Tuberc Lung Dis. 2016 Jan;20(1):11-23
Future impact of various interventions on the burden of COPD in Canada: a dynamic population model.
PLoS One. 2012;7(10):e46746
Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
Lancet Respir Med. 2015 Aug;3(8):631-9
The Projected Epidemic Of COPD Hospitalizations Over the Next 15 Years: A Population Based Perspective
Am J Respir Crit Care Med. 2017 Feb 1;195(3):287-291
Excess economic burden of comorbidities in COPD: a 15-year population-based study
Eur Respir J. 2017 Jul 27;50(1). pii: 1700393
Heterogeneity’s ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations
Thorax. 2014 Nov;69(11):1043-4
A systematic review of health economics simulation models of chronic obstructive pulmonary disease
Value Health. 2017;20(1):152–162
Predicting severe COPD exacerbations: A population surveillance approach with administrative data
An individualized prediction model for long-term lung function trajectory and risk of COPD in the general population
Chest. 2019 Sep 19. pii: S0012-3692(19)33868-1
Trends in prescriptions and costs of inhaled medications in chronic obstructive pulmonary disease: a 19-year population-based study from Canada
Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:2003-2013
The Relationship between Body Mass Index and Rate of Lung Function Decline among COPD Patients: a nonlinear regression analysis
In pooled data of 10,759 COPD patients from 7 clinical trials (median follow up of 5 years), we examined the non-linear relationships of BMI with the rate of decline in Forced Expiratory Volume in One Second (FEV1) using restricted cubic spline regressions...
In pooled data of 10,759 COPD patients from 7 clinical trials (median follow up of 5 years), we examined the non-linear relation...
Heterogeneity in the respiratory symptoms of patients with mild-moderate COPD
Using data from a population-based prospective cohort, we assessed the burden of self reported respiratory symptoms in patients with persistent airflow limitation in order to (1) characterize variation in the occurrence of symptoms between individuals, and...
Using data from a population-based prospective cohort, we assessed the burden of self reported respiratory symptoms in patients...
Ten-Year Trends in Direct Costs of COPD: A Population-Based Study.
Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagnosed COPD from 2001 to 2010 in British Columbia. The secondary objectives were to evaluate the relative contributions of the var...
Our primary objective in this study was to estimate the excess direct costs related to the care of patients with physician-diagn...
The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology.
Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated potential causal associations among past and future severe exacerbations, albeit the magnitude of association was noticeably low...
Using robust statistical methodology that controlled for heterogeneity in exacerbation rates among individuals, we demonstrated...
Moving beyond AUC: decision curve analysis for quantifying net benefit of risk prediction models
Eur Respir J. 2021 Sep 9:2101186. doi: 10.1183/13993003.01186-2021
The Acute COPD Exacerbation Prediction Tool (ACCEPT): a modelling study
This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors
Cost-Effectiveness of Case Detection Strategies for the Early Detection of COPD
Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence to guideline-recommended treatment following diagnosis.
Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence t...
The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model
Am J Epidemiol. 2016;184(9):681–689
History of Asthma in Patients with Chronic Obstructive Pulmonary Disease: A Comparative Study of Economic Burden.
Ann Am Thorac Soc. 2016 Feb;13(2):188-96
Long-term effects of inhaled corticosteroids on bone mineral density in older women with asthma or COPD: a registry-based cohort study
Arch Osteoporos. 2018 Oct 29;13(1):116
Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap.
Lancet Respir Med. 2016 Jun;4(6):421-2
RELATED IPRESS WEBAPP:
Acute COPD Exacerbation Prediction Tool (ACCEPT)
Acute COPD Exacerbation Predicti...
Burden of Diagnosed COPD in Canada
Burden of Diagnosed COPD in Cana...
Lung Function Predictor for the General Population
Lung Function Predictor for the...
Joint-rate severity modeling of (recurrent) events
Joint-rate severity modeling of...
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