THE UNIVERSITY OF BRITISH COLUMBIA
Project status
PUBLICATIONS:
Epidemiology. 2022 Jul 1;33(4):555-558. doi: 10.1097/EDE.0000000000001489.
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Medical Decision Making. October 2021. doi:10.1177/0272989X211050909
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Sadatsafavi M, Yoon Lee T, Gustafson P. Uncertainty and the Value of Information in Risk Prediction Modeling. Med Decis Making. 2022 Jul;42(5):661-671. doi: 10.1177/0272989X221078789.
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Med Decis Making. 2023 Jul;43(5):564-575. doi: 10.1177/0272989X231178317.
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Diagn Progn Res. 2023 May 16;7(1):10. doi: 10.1186/s41512-023-00147-z
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Stat Med. 2024 Jun 11. doi: 10.1002/sim.10138.
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Lee TY, Price D, Yadav CP, Roy R, Mien LLH, Wang E, Wechsler ME, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Mahboub B, Perng Steve DW, Cosio BG, Perez-de-Llano L, Al-Lehebi R, Larenas-Linnemann D, Al-Ahmad M, Rhee CK, Iwanaga T, Heffler E, Canonica GW, Co...
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Amegadzie JE, Gao Z, Quint JK, Russell R, Hurst JR, Lee TY, Sin DD, Chen W, Bafadhel M, Sadatsafavi M. QRISK3 underestimates the risk of cardiovascular events in patients with COPD. Thorax. 2023 Nov 27:thorax-2023-220615. doi: 10.1136/thorax-2023-220615. E...
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Ahmadian S, Johnson KM, Ho JK, Sin DD, Lynd LD, Harrison M, Sadatsafavi M. A Cost-Effectiveness Analysis of Azithromycin for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2023 Dec;20(12):1735-1742. doi:...
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Adibi A, Barn P, Shellington EM, Harvard S, Johnson KM, Carlsten C. High-Efficiency Particulate Air Filters for Preventing Wildfire-related Asthma Complications: A Cost-Effectiveness Study. Am J Respir Crit Care Med. 2024 Jan 15;209(2):175-184. doi: 10.116...
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Ho JK, Shaker M, Greenhawt M, Sadatsafavi M, Abrams EM, Oppenheimer J, Mosnaim GS, Lee TY, Johnson KM. Cost-effectiveness of budesonide-formoterol vs inhaled epinephrine in US adults with mild asthma. Ann Allergy Asthma Immunol. 2023 Oct 23:S1081-1206(23)0...
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Amegadzie JE, Sadatsafavi M. A long overdue recognition: COPD as a distinct predictor of cardiovascular disease risk. Eur Respir J. 2023 Aug 31;62(2):2301167. doi: 10.1183/13993003.01167-2023
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Amegadzie JE, Lee TY, Sadatsafavi M, Lynd LD, Sin DD, Johnson KM. Trends in hospital admissions for chronic obstructive pulmonary disease over 16 years in Canada. CMAJ. 2023 Sep 11;195(35):E1172-E1179. doi: 10.1503/cmaj.221051.
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Can Fam Physician. 2023 Jun;69(6):409-414. doi: 10.46747/cfp.6906409. PMID: 37315968; PMCID: PMC10266388.
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IMPACT Study. Generalizability of Risk Stratification Algorithms for Exacerbations in COPD. Chest. 2023 Apr;163(4):790-798. doi: 10.1016/j.chest.2022.11.041
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Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials. Respir Res. 2023 May 2;24(1):120. doi: 10.1186/s12931-023-02409-2.
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A parametric model to jointly characterize rate, duration, and severity of exacerbations in episodic diseases. BMC Med Inform Decis Mak. 2023 Jan 12;23(1):6. doi: 10.1186/s12911-022-02080-5
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IMPACT Study Group. IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized impact study. Diagn Progn Res. 2023 Feb 14;7(1):3. doi: 10.1186/s41512-023-00140-6
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Individualised risk prediction model for exacerbations in patients with severe asthma: protocol for a multicentre real-world risk modelling study. BMJ Open. 2023 Mar 9;13(3):e070459. doi: 10.1136/bmjopen-2022-070459
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Michaux KD, Metcalfe RK, Burns P, Conklin AI, Hoens AM, Smith D, Struik L, Safari A, Sin DD, Sadatsafavi M; IMPACT Study Group. IMplementing Predictive Analytics towards efficient COPD Treatments (IMPACT): protocol for a stepped-wedge cluster randomized im...
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Harvard S, Werker GR. Health Economists on Involving Patients in Modeling: Potential Benefits, Harms, and Variables of Interest. Pharmacoeconomics. 2021 Jul;39(7):823-833. doi: 10.1007/s40273-021-01018-5.
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Harvard S, Winsberg E, Symons J, Adibi A. Value judgments in a COVID-19 vaccination model: A case study in the need for public involvement in health-oriented modelling. Soc Sci Med. 2021 Oct;286:114323. doi: 10.1016/j.socscimed.2021.114323.
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Harvard, S., & Winsberg, E. (2021). Causal Inference, Moral Intuition, and Modeling in a Pandemic. Philosophy of Medicine, 2(2). https://doi.org/10.5195/pom.2021.70
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Harvard S, Winsberg E. The Epistemic Risk in Representation. Kennedy Inst Ethics J. 2022;32(1):1-31. doi: 10.1353/ken.2022.0001. PMID: 35431275.
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Winsberg E, Harvard S. Purposes and duties in scientific modelling. J Epidemiol Community Health. 2022 Jan 13:jech-2021-217666. doi: 10.1136/jech-2021-217666.
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Adibi A, Turvey SE, Lee TY, Sears MR, Becker AB, Mandhane PJ, Moraes TJ, Subbarao P, Sadatsafavi M. Development of a conceptual model of childhood asthma to inform asthma prevention policies. BMJ Open Respir Res. 2021 Nov;8(1):e000881. doi: 10.1136/bmjresp...
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Lee TY, Petkau J, Sadatsafavi M. Long-Term Natural History of Severe Asthma Exacerbations and Their Impact on the Disease Course. Ann Am Thorac Soc. 2022 Jun;19(6):907-915. doi: 10.1513/AnnalsATS.202012-1562OC.
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Puhan MA, Sadatsafavi M. Validation of the 4C prediction models to inform care for patients with COVID-19: final steps towards clinical application. Thorax. 2022 Jun;77(6):536. doi: 10.1136/thoraxjnl-2021-218313.
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Sadatsafavi M, Aaron SD, Gershon AS, Puhan M, Adibi A, Sin DD. The Hidden and Unchecked Judgement Calls When Using Exacerbation History for Managing COPD. Arch Bronconeumol. 2022 Sep;58(9):629-631. English, Spanish. doi: 10.1016/j.arbres.2021.09.018.
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Ahmadian S, Sin DD, Lynd L, Harrison M, Sadatsafavi M. Benefit-harm analysis of azithromycin for the prevention of acute exacerbations of chronic obstructive pulmonary disease. Thorax. 2022 Nov;77(11):1079-1087. doi: 10.1136/thoraxjnl-2021-217962.
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Gupta S, Panchal P, Sadatsafavi M, Ghanouni P, Sin D, Pakhale S, To T, Zafari Z, Nimmon L; Canadian Respiratory Research Network. A personalized biomedical risk assessment infographic for people who smoke with COPD: a qualitative study. Addict Sci Clin Pra...
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Longo C, Blais L, Brownell M, Quail JM, Sadatsafavi M, Forget A, Turcot MA, Li W, Sidhu N, Tavakoli H, Tan Q, Platt RW, Ducharme FM. Association Between Asthma Control Trajectories in Preschoolers and Long-Term Asthma Control. J Allergy Clin Immunol Pract....
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Zafari Z, Lee TY, Sadatsafavi M. External validation of lung function predictions in real-world cohorts of COPD. Respir Med. 2022 Jul;198:106859. doi: 10.1016/j.rmed.2022.106859.
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Lee TY, Petkau J, Mangat N, Safari A, Cragg JJ, Lynd LD, FitzGerald JM, Turvey SE, Sadatsafavi M. 16-year trends in asthma hospital admissions in Canada. Ann Allergy Asthma Immunol. 2022 Oct;129(4):475-480.e2. doi: 10.1016/j.anai.2022.06.022.
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Golam SM, Janson C, Beasley R, FitzGerald JM, Harrison T, Chipps B, Hughes R, Müllerová H, Olaguibel JM, Rapsomaniki E, Reddel HK, Sadatsafavi M; NOVELTY study investigators. The burden of mild asthma: Clinical burden and healthcare resource utilisation in...
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Safari A, Adibi A, Sin DD, Lee TY, Ho JK, Sadatsafavi M. ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exacerbation prediction tool (ACCEPT). EClinicalMedicine. 2022 Jul 22;51:101574. doi: 10.1016/j.eclinm.2022.101574.
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Harvard S, Adibi A, Easterbrook A, Werker GR, Murphy D, Grant D, Mclean A, Majdzadeh Z, Sadatsafavi M. Developing an online infrastructure to enhance model accessibility and validation: The Peer Models Network. Pharmacoeconomics. 2022 Oct;40(10):1005-1009....
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Ho JK, Safari A, Adibi A, Sin DD, Johnson K, Sadatsafavi M; IMPACT study. Generalizability of risk stratification algorithms for exacerbations in COPD. Chest. 2022 Dec 9:S0012-3692(22)04216-7. doi: 10.1016/j.chest.2022.11.041.
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The demonstrable value of precision medicine, in the context of common environmental exposures, has scarcely been explored. This study evaluated the cost effectiveness of a preventive personalised intervention to reduce the adverse effect of air pollution...
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Respir Res. 2021 Apr 9;22(1):103. doi: 10.1186/s12931-021-01696-x
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Eur Respir J. 2021 Sep 9:2101186. doi: 10.1183/13993003.01186-2021
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Allergy Asthma Clin Immunol. 2021 Oct 12;17(1):108. doi: 10.1186/s13223-021-00610-w. PMID: 34641954.
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Med Decis Making. 2019 Feb;39(2):152-16
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JAMA. 2020 Jul 21;324(3):235-236
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We agree with Drs Goldstein and Pencina about the necessity of adapting risk models to the clinical use case. We share their vision that a cloud-based platform does not have to be centralized; each practitioner will set up their own environment for the mod...
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The International Severe Asthma Registry (ISAR) is a collaborative initiative comprising existing and new registries that builds on data from multiple nations and regions and increases the statistical power and comparability of data. It is the first global...
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The aim of this study is to develop a platform that allows: 1) policymakers to identify subgroups of the COPD population that are at increased risk of emergency department visits, hospitalization and mortality and 2) health economists to obtain input or va...
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There is sparse evidence that COPD exacerbations are associated with subsequent accelerated lung function decline, particularly in those with mild disease. Lung function decline is most accelerated at the early stages of COPD, and early identification of p...
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Eur Respir J. 2020 Aug 27;2002122. doi: 10.1183/13993003.02122-2020.
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Ann Am Thorac Soc. 2020 May 8.
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Respir Res. 2020 May 19;21(1):118
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Respiratory Medicine, 2020 (171); 106079
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The purpose of this clinical practice guideline is to address specific clinically important questions regarding the pharmacologic management of COPD. The expert panel, in collaboration with a team of methodologists, prioritized and developed six questions...
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This Lancet Respiratory Medicine describes a new prediction model to predict COPD exacerbations using simple clinical predictors
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Statistic in Medicine. 2020;10.1002/sim.8481
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A comment on the study "Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD" by Wijnant et al. Given that PRISm resembles COPD in term of reduction in FEV1, but not in terms of FEV1/FVC r...
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J Allergy Clin Immunol. 2019;S0091-6749(19)31634-3
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Am J Epidemiol. 2016;184(9):681–689
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CMAJ. 2016;188(14):1004–1011
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J Gen Intern Med. 2018 Sep;33(9):1528-1535
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J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1663-1670.e5
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BMJ Open. 2013 Sep 4;3(9):e003360
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Ann Am Thorac Soc. 2016 Feb;13(2):188-96
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Chest. 2014 Apr;145(4):787-793
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Respir Res. 2016 Aug 26;17(1):106
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Arch Osteoporos. 2018 Oct 29;13(1):116
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J Asthma. 2019 Dec;56(12):1334-1346
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Clin Epidemiol. 2018 Jul 12;10:831-840
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Respir Res. 2018 Feb 7;19(1):26
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Respir Res. 2018 Feb 7;19(1):26
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Cost Eff Resour Alloc. 2018 Jan 30;16:3
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Int J Tuberc Lung Dis. 2014 Mar;18(3):254
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Respir Med. 2018 May;138:7-12
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Ann Epidemiol. 2018 Oct;28(10):717-723.e3
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Pharmacoeconomics. 2014 Oct;32(10):995-1004
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Chest. 2015 Apr;147(4):868-869
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Int J Tuberc Lung Dis. 2016 Jan;20(1):11-23
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PLoS One. 2012;7(10):e46746
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Chest. 2017 Mar;151(3):612-618
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BMC Pulm Med. 2018 Feb 12;18(1):33.
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Thorax. 2014 Apr;69(4):328-34
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J Allergy Clin Immunol. 2013 Jul;132(1):63-9
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J Clin Epidemiol. 2010 Mar;63(3):257-69
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Lancet Respir Med. 2015 Aug;3(8):631-9
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Med Care. 2016 Aug;54(8):789-95
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Eur Respir J. 2016 Dec;48(6):1584-1592
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Allergy. 2017 Feb;72(2):291-299
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J Allergy Clin Immunol. 2014 Oct;134(4):908-915.e3
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Am J Respir Crit Care Med. 2017 Feb 1;195(3):287-291
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Thorax. 2016 Mar;71(3):267-75
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PLoS One. 2016 Jan 11;11(1):e0146003
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Trials. 2014 Jun 3;15:201
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Cost Eff Resour Alloc. 2014 Mar 13;12(1):8
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Health Econ. 2013 Jul;22(7):877-82
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Value Health. 2013 Jan-Feb;16(1):66-75
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Eur Respir J. 2017 Jul 27;50(1). pii: 1700393
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PUBLICATIONS:
Med Decis Making. 2023 Jul;43(5):621-626
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arXiv:2202.08358v2
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Does the occurrence of a severe asthma exacerbation affect the rate of subsequent events? To the best of our knowledge, this important question has not been evaluated in asthma. Conventional wisdom is that previous history of asthma exacerbations is the be...
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Primary care-based programs for improving the early detection of COPD are very likely to be cost-effective with high adherence to guideline-recommended treatment following diagnosis.
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